5 edition of Dendritic spines biochemistry, modeling and properties found in the catalog.
Dendritic spines biochemistry, modeling and properties
Includes bibliographical references and index.
|Statement||[edited by] Louis R. Baylog.|
|Contributions||Baylog, Louis R.|
|LC Classifications||QP364 .D46 2009|
|The Physical Object|
|LC Control Number||2009018834|
Dendritic spines as chemical and electrical compartments: A two-photon imaging study in the properties and postsynaptic receptor densities. combined with modeling, we predicted that EPSPs reach amplitudes of ~55 mV in functional spines, . Dendritic spines are small protrusions consisting of a head bearing the postsynaptic components of excitatory synapses and a neck connecting the spine head to the dendritic shaft. The structure of heads and necks varies considerably among different spines within the cortex and hippocampus (Harris and Kater ) and over time (Fischer et al Cited by:
Dendritic spines are the main targets of most excitatory synapses in the cerebral cortex. They are believed to provide chemical compartmentalisation and to participate as key elements in neural computation, including synaptic plasticity and altered integration in neurodegenerative diseases. dendritic spines (Chicurel and Harris, ). Cytoskeleton and cytoplasm A loose network of filaments characterizes the cytoskeleton of dendritic spines. Spine cytoskeleton differs from dendrite cytoskeleton by the absence of microtubules in spines, except for the occasional microtubule in highly complex spines.
Neuron Article Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation Miquel Bosch,1,2,* Jorge Castro,2,5 Takeo Saneyoshi,3,5 Hitomi Matsuno,3 Mriganka Sur,2 and Yasunori Hayashi1,2,3,4,* 1RIKEN-MIT Neuroscience Research Center 2The Picower Institute for Learning and Memory, Department of Brain and Cognitive . Dendritic spines receive the majority of excitatory connections in the central nervous system, and, thus, they are key structures in the regulation of neural activity. Hence, the cellular and molecular mechanisms underlying their generation and plasticity, both during development and in adulthood, are a matter of fundamental and practical interest. Indeed, a better understanding of these Cited by:
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Free Online Library: Dendritic spines biochemistry, modeling and properties.(Neuroscience research progress, Brief article, Book review) by "SciTech Book News"; Publishing industry Library and information science Science and technology, general Books Book. The contribution of reproductive experience, steroid and peptide hormones on dendritic spine density and morpholology in the hippocampus and prefrontal cortex / Tamara M.
Crozier [and others] --The actin cytoskeleton: central regulator of dendritic spine form and function / Andreas Birbach --Pathological remodeling of dendritic spines / John N.
Dendritic Spines: Biochemistry, Modeling and Properties (Neuroscience Research Progress): Medicine & Health Science Books @ In Dendritic Spines, leading neurobiologist Rafael Yuste attempts to solve the “spine problem,” searching for the fundamental function of spines.
He does this by examining many aspects of spine biology that have fascinated him over the years, including their structure, development, motility, plasticity, biophysical properties, and calcium Cited by: Small bud-like extensions (dendritic spines, Fig. C) of a variety of shapes are frequently seen on the more distal dendrites (Figs.
and B, C). These are sites of synaptic contacts (discussed later). The branches of dendrites increase in. Dendritic Spine. Dendritic spines modeling and properties book the target for most excitatory inputs in pyramidal neurons in the cerebral cortex and in cerebellar Purkinje cells, as well as in a variety of other neuron types, so an understanding of their properties is critical for understanding brain function (Alvarez and Sabatini, ; Araya et al., ; Shepherd, ).
Introduction. Inthe legendary neuroanatomist Ramón y Cajal was the first to describe dendritic spines on neurons .Since this first description, technical Dendritic spines biochemistry have driven our knowledge of the structural and functional properties of dendritic spines but the function of spines remains the subject of intense study and debate [2,3].
Cited by: 1. Author(s): Baylog,Louis R Title(s): Dendritic spines: biochemistry, modeling and properties/ Louis R. Baylog, editor. Country of Publication: United States.
Haptically Assisted Connection Procedure for the Reconstruction of Dendritic Spines Dendritic Spines: Biochemistry, Modeling and Properties.
April This book. Many types of neurons receive synaptic inputs on dendritic spines which are short protrusions of membrane composed of a bulbous “head” connected to the dendrite by a thin “stem” or “neck” (Yuste ).Although spines are typically small in size, they occur in high densities along dendrites and may compose 40–60 % of the total dendritic surface area.
Dendritic spines A dendritic spine is a small membranous protrusion on a neuron that receives input from a synapse of another neuron. A spine is typically located on peripheral dendrites, but can also be located on proximal dendrites or even the cell body.
Dendritic spines are important sites for excitatory synaptic interactions and they play an important role in neural plasticity, while their ability to regulate calcium has attracted the interest.
Spines are neuronal protrusions, each of which receives input typically from one excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling systems essential for synaptic function and plasticity.
Numerous brain disorders are associated with abnormal dendritic spines. Spine formation, plasticity, and maintenance depend on synaptic activity and can be Cited by: A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity.
Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on a tree. But a hundred and twenty years after. dendritic spines: variably long excrescences of nerve cell dendrites, varying in shape from small knobs to thornlike or filamentous processes, usually more numerous on distal dendrite arborizations than on the proximal part of dendritic trunks.
Dentritic spines are a preferential site of synaptic axodendritic contact; they are sparse or absent. The actin cytoskeleton in dendritic patches (left), dendritic filopodia (middle), and dendritic spines (right) has similar organization consisting of a mixed network of linear and branched actin filaments (blue) anchored to microtubules (red) or.
The majority of fast excitatory synaptic transmission in the central nervous system takes place at protrusions along dendrites called spines. Dendritic spines are highly heterogeneous, both morphologically and functionally.
Not surprisingly, there has been much speculation and debate on the relationship between spine structure and function.
The advent of multi-photon laser Cited by: Distinctive Structural Features of Dendritic Spines Spine morphology Dendritic spines have a wide variety of sizes, shapes and subcellular compositions, both within and across brain regions.
Most spines can be classified by their shapes as stubby, thin or mushroom-shaped (Figure 2a). Occasionally, dendritic spines have multiple.
Most excitatory inputs in the CNS contact dendritic spines, avoiding dendritic shafts, so spines must play a key role for neurons. Recent data suggest that, in addition to enhancing connectivity and isolating synaptic biochemistry, spines can behave as electrical compartments independent from their parent dendrites.
It is becoming clear that, although spines experience voltages Cited by: Modeling predicts that molecular trapping by dendritic spines causes diffusion along spiny dendrites to be anomalous and that the value of the anomalous exponent (d w) is proportional to spine density in both cell types.
To test these predictions we combined the local photorelease of an inert dye, rhodamine dextran, with two-photon fluorescence.
Synonyms for Spines in Free Thesaurus. Antonyms for Spines. 46 synonyms for spine: backbone, vertebrae, spinal column, vertebral column, barb, spur, needle, spike.
Dendritic spines are in the spotlight of contemporary neuroscience research. Variations in normal brain function (e.g. intelligence, memory, motivation) and neuropathological disorders (e.g. dementias, epilepsy, schizophrenia, bipolar disorders.Consequently, in a study of the electrical properties of dendritic spines the input impedance of the parent dendrite, the spinestalk conductance and the conductance change associated with synaptic activity must be considered.
We quantitatively estimated all three by: